Patent · US Active

Bispecific binding agents for modulating biological activity

US8124085B2 · kind B2 · utility

23Cited by

2References

9Claims

0Family size

Assignee

Merrimack Pharmaceuticals, Inc. · US

Inventors

Ulrik Nielsen · Quincy, US
Birgit Schoeberl · Cambridge, US

Key dates

Filing date	May 5, 2005
Grant date	Feb 28, 2012
Priority date	—
Expiry date	Jun 10, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Methods for improving the biological and pharmaceutical properties of bispecific binding agents are described herein where the bispecific binding agent are able to target cells by a high affinity binding domain to a first cell surface marker that does not induce a significant biological effect and a low affinity binding domain that binds specifically to a second cell surface marker, causing a significant and desired biological effect. Compositions of such bispecific binding agents, uses for them, and kits containing them are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.