Quantification of fusion proteins and their activity from chromosomal translocation
US8124351B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 14, 2006 |
| Grant date | Feb 28, 2012 |
| Priority date | — |
| Expiry date | Feb 7, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/57426
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention concerns the detection of gene products resulting from chromosomal translocations, including fusion proteins comprising a first and second region. In particular, the fusion proteins are identified following subjecting a sample comprising the proteins to a bead comprising an antibody to a first region, followed by subjecting the bead-antibody-fusion complex to a second antibody directed against the second region, thereby detecting the fusion protein. In particular aspects, the invention is employed to provide prognosis for an individual with cancer, to identify suitability for a particular cancer therapy, and/or to monitor response of a patient to a therapy, for example.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.