Crystal structure of aldehyde dehydrogenase and methods of use thereof
US8124389B2 · kind B2 · utility
5Cited by
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6Claims
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Key dates
| Filing date | May 4, 2009 |
| Grant date | Feb 28, 2012 |
| Priority date | — |
| Expiry date | Aug 13, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2299/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general terms, the method comprises computationally identifying a compound that binds to an ALDH polypeptide, using the atomic coordinates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.