Patent · US Active

Utilizing liver cell line QSG-7701 to be infected with hepatitis B virus

US8124409B2 · kind B2 · utility

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Key dates

Filing dateJan 29, 2008
Grant dateFeb 28, 2012
Priority date—
Expiry dateAug 10, 2028

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2730/10151
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The use of the liver cell line QSG-7701 for HBV infection includes the following steps: directly infecting QSG-7701 cells with purified HBV particles and facilitating the infection by DMSO and/or PEG treatment. The easily available QSG-7701 liver cell line may not require pre-differentiation induction and is naturally susceptible for HBV infection. This cell line provides near normal physiological conditions for HBV infection, especially the infection conditions that are characterized with Chinese origin. This cell line is suitable for investigating the life cycle of HBV. Therefore, this cell line is useful for the investigation of viral infection processes and for the development of drugs that specifically target these processes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.