2-(aminomethyl)-5-chlorobenzylamide derivatives and their use as inhibitors of the clotting factor Xa

US8124587B2 · kind B2 · utility

Assignee

• THE MEDICINES COMPANY (LEIPZIG) GMBH · DE

Inventors

• Torsten Steinmetzer · Jena, DE
• Daniel Doennecke · Weimar, DE
• Andrea Schweinitz · Jena, DE
• Anne Stuerzebecher · Weimar, DE
• Joerg Stuerzebecher · Erfurt, DE

Key dates

• Filing date: Sep 18, 2006
• Grant date: Feb 28, 2012
• Expiry date: Dec 15, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06086
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

2-(Aminomethyl)-5-chlorobenzylamide derivatives and their use as inhibitors of coagulation factor Xa are provided. The compounds are suitable for the treatment and prophylaxis of cardiovascular and thrombotic events.