Patent · US Active

Chimeric plasminogen activators and their pharmaceutical use

US8124588B2 · kind B2 · utility

1Cited by

9References

28Claims

0Family size

Assignee

JUSTUS-LIEBIG-UNIVERSITAET GIESSEN · DE

Inventors

Werner Seeger · Gießen, DE
Andreas GÜNTHER · Gießen, DE
Clemens Ruppert · Gießen, DE
Philipp Markart · Gießen, DE
Viktor Magdolen · Tauberbischofsheim, DE
Timothy E. Weaver · Loveland, US

Key dates

Filing date	Dec 18, 2003
Grant date	Feb 28, 2012
Priority date	—
Expiry date	Jun 2, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y304/21073
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to recombinant chimeric proteins comprising a surfactant protein precursor N-terminally fused to a plasminogen activator or comprising a mature surfactant protein N-terminally or C-terminally fused to a plasminogen activator. The invention is also directed to the corresponding nucleic acid molecules encoding such fusion proteins as well as to a method for their production. The invention further refers to a pharmaceutical composition comprising such a fusion protein and to pharmacological uses of an inventive fusion protein for the prevention and/or treatment of inflammatory and interstitial lung diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.