Sodium channel inhibitors

US8124610B2 · kind B2 · utility

Assignee

• Icagen, LLC · US

Inventors

• Alan Bradley Fulp · Fuquay-Varina, US
• Matthew Scott Johnson · Durham, US
• Christopher John Markworth · Durham, US
• Brian Edward Marron · Durham, US
• Darrick Seconi · Cary, US
• Christopher William West · El Sobrante, US
• Xiaodong Wang · Zhejiang, CN
• Shulan Zhou · Durham, US

Key dates

• Filing date: Jul 14, 2008
• Grant date: Feb 28, 2012
• Expiry date: Mar 8, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.