Bicyclic PPAT inhibitors as antibacterial agents
US8124616B2 · kind B2 · utility
5Cited by
7References
11Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 26, 2008 |
| Grant date | Feb 28, 2012 |
| Priority date | — |
| Expiry date | Nov 16, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are compounds of Formula I, pharmaceutical compositions comprising Formula I and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.