Tricyclic compounds useful as angiotensin II agonists

US8124638B2 · kind B2 · utility

Assignee

• VICORE PHARMA AB · SE

Inventors

• Mathias Alterman · Stockholm, SE
• Anders Hallberg · Stockholm, SE

Key dates

• Filing date: Sep 3, 2009
• Grant date: Feb 28, 2012
• Expiry date: Sep 3, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided compounds of formula (I), wherein X1, X2, X3, Y4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.