Process for the preparation of 4-{4-[({[4 chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide

US8124782B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Michael Logers · Wuppertal, DE
• Reinhold Gehring · Wuppertal, DE
• Oliver Kuhn · Konz, DE
• Mike Matthaus · Wuppertal, DE
• Klaus-Helmut Mohrs · Wuppertal, DE
• Matthias Muller-Gliemann · Haan, DE
• Jürgen Stiehl · Winsen (Aller), DE
• Mathias Berwe · Sprockhövel, DE
• Jana Lenz · Wuppertal, DE
• Werner Heilmann · Wuppertal, DE

Key dates

• Filing date: Sep 20, 2005
• Grant date: Feb 28, 2012
• Expiry date: Apr 29, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoro-methyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide and its tosylate salt.