Patent · US Active

Ketol-acid reductoisomerase using NADH

US8129162B2 · kind B2 · utility

43Cited by

0References

4Claims

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Assignee

Butamax Advanced Biofuels LLC · US

Inventors

Yougen Li · Pennington, US
Der-Ing Liao · Wilmington, US
Mark J. Nelson · Newark, US
Daniel P. Okeefe · Swarthmore, US

Key dates

Filing date	Dec 18, 2008
Grant date	Mar 6, 2012
Priority date	—
Expiry date	Dec 18, 2028

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02E50/10
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.