Antisense antiviral compound and method for treating ssRNA viral infection
US8129352B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 14, 2005 |
| Grant date | Mar 6, 2012 |
| Priority date | — |
| Expiry date | Sep 14, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Arteriviridae, Coronaviridae, Astroviridae and Hepeviridae families in the treatment of a viral infection. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with stem-loop secondary structure within the 5′-terminal end 40 bases of the positive-sense RNA strand of the virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.