Screening molecules with anti-prion activity: kits, methods and screened molecules
US8129402B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 20, 2003 |
| Grant date | Mar 6, 2012 |
| Priority date | — |
| Expiry date | Oct 11, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity characterized in that they comprise in combination a [PSI+], phenotype yeast, an antibiogram and an agent for purifying prions at sub-efficient doses, said yeast including the adel-14 allele of the ADE1 gene and an inactivated ERG6 gene, the screening methods, and a family of molecules with anti-prion activity isolated by the inventive screen. The invention is applicable to anti-prion agents for producing medicines in particular for treating neurodegenerative diseases involving protein aggregates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.