Small organic molecule regulators of cell proliferation

US8129425B2 · kind B2 · utility

Assignee

• Curis, Inc. · US

Inventors

• Anthony David Baxter · Hertford, GB
• Edward Andrew Boyd · Biggenden, AU
• Maria Frank-Kamenetsky · Brookline, US
• Oivin Guicherit · San Diego, US
• Jeffery Porter · Lexington, US
• Stephen Price · Hertford, GB
• Lee L. Rubin · Wellesley, US
• John Harry Alexander Stibbard · Biggenden, AU

Key dates

• Filing date: Apr 27, 2006
• Grant date: Mar 6, 2012
• Expiry date: Nov 30, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.