Patent · US Active

Water-soluble artemisinin derivatives, their preparation methods, the pharmaceutical compositions and the use thereof

US8129426B2 · kind B2 · utility

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2Claims

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Assignee

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Ying Li · Millburn, US
Jianping Zuo · Shanghai, CN
Zhongshun Yang · Shanghai, CN
Junxia Wang · Shanghai, CN
Yu Zhang · Sichuan, CN
Wei Tang · Shanghai, CN
Jianxin Zhang · Acton, US

Key dates

Filing date	Jul 20, 2006
Grant date	Mar 6, 2012
Priority date	—
Expiry date	Jan 21, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P37/06
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Water-soluble artemisinin derivatives, their preparation methods, the pharmaceutical compositions containing the same derivatives and the use thereof are disclosed. The artemisinin derivatives have following formula I. It has been proved by pharmacological tests that these compounds and compositions have evident immuno-suppressive activities, and may be used in the preparation of novel immuno-suppressants for treating the diseases caused by hyperfunction of human immunity (e.g. the auto-immune diseases such as lupus erythematosus, rheumatoid arthritis, multiple sclerosis and the like), and for inhibiting the graft rejection after cell or organ transplantation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.