Automated in vivo plaque composition evaluation
US8131336B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 1, 2006 |
| Grant date | Mar 6, 2012 |
| Priority date | — |
| Expiry date | Jan 5, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30101
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method for the automated segmentation of in vivo image data is disclosed. A region of carotid artery in a number of patients was imaged using MRI. Histological data for each imaged region was then obtained, identifying various atherosclerotic plaque components in the imaged region. A portion of the histological data, and the image data, was used to generate PDFs based on image intensity, and on morphological data (local wall thickness and distance from lumen). The remaining data was used to validate the method. A plurality of MRI images were taken at various weightings, and the images were registered and normalized. The lumen and outer wall boundary were identified. The PDFs were combined in a Bayesian analysis with the intensity and morphological data to calculate the likelihood that each pixel corresponded to each of four plaque components. A contour algorithm was applied to generate contours segmenting the images by composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.