Methods and apparatus for monopolar renal neuromodulation

US8131371B2 · kind B2 · utility

Assignee

• Ardian, Inc. · US

Inventors

• Denise Demarals · Los Gatos, US
• Hanson S. Gifford, III · Woodside, US
• Mark Deem · Mountain View, US
• Howard R. Levin · Teaneck, US
• Mark Gelfand · New York, US
• Nicolas Zadno · Fremont, US

Key dates

• Filing date: Apr 13, 2006
• Grant date: Mar 6, 2012
• Expiry date: Mar 26, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/327
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.