Method for identifying agents capable of inhibiting APOBEC3C activity in HIV-infected cells
US8133666B2 · kind B2 · utility
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1References
8Claims
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Key dates
| Filing date | Oct 31, 2005 |
| Grant date | Mar 13, 2012 |
| Priority date | — |
| Expiry date | Nov 10, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods of identifying agents that reduce a level of active APOBEC3C in a cell. The present invention provides agents that reduce a level of active APOBEC3C in a cell; and compositions comprising the agents. The present invention further provides methods of reducing the mutation rate of a lentivirus in a cell; and methods of reducing the emergence of drug-resistant strains of lentivirus. The present invention further provides methods for treating lentivirus infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.