Fluorescence polarization hERG assay
US8133695B2 · kind B2 · utility
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3References
34Claims
0Family size
Assignee
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Key dates
| Filing date | Feb 27, 2009 |
| Grant date | Mar 13, 2012 |
| Priority date | — |
| Expiry date | Nov 5, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/13
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.