Human androgen receptor alternative splice variants as biomarkers and therapeutic targets
US8133724B2 · kind B2 · utility
18Cited by
1References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 17, 2009 |
| Grant date | Mar 13, 2012 |
| Priority date | — |
| Expiry date | Sep 17, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/14
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and/or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.