Method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury

US8133866B2 · kind B2 · utility

Assignees

• The Trustees of Columbia University in the City of New York · US
• The Cleveland Clinic Foundation · US

Inventors

• David M. Stern · Great Neck, US
• Ann Marie Schmidt · Franklin Lakes, US
• Steven Marso · Shawnee, US
• Eric Topol · Village of La Jolla, US
• A. Michael Lincoff · Warrensville Heights, US

Key dates

• Filing date: Jun 7, 2010
• Grant date: Mar 13, 2012
• Expiry date: Jun 7, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/5088
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides for a method for inhibiting new tissue growth in blood vessels in a subject, wherein the subject experienced blood vessel injury, which comprises administering to the subject a pharmaceutically effective amount of an inhibitor of receptor for advanced glycation endproduct (RAGE) so as to inhibit new tissue growth in the subject's blood vessels. The invention also provides for method for inhibiting neointimal formation in blood vessels in a subject, wherein the subject experienced blood vessel injury, which comprises administering to the subject a pharmaceutically effective amount of an inhibitor of receptor for advanced glycation endproduct (RAGE) so as to inhibit neointimal formation in the subject's blood vessels. The invention also provides a method for preventing exaggerated restenosis in a diabetic subject which comprises administering to the subject a pharmaceutically effective amount of an inhibitor of receptor for advanced glycation endproduct (RAGE) so as to prevent exaggerated restenosis in the subject.