Carbohydrate conjugates to prevent abuse of controlled substances

US8133881B2 · kind B2 · utility

Assignee

• Shire LLC · US

Inventors

• Travis Mickle · Four Corners, US
• Thomas Piccariello · Blacksburg, US
• James Scott Moncrief · Christiansburg, US
• Nancy Boerth · Blacksburg, US
• Barney Bishop · Annandale, US

Key dates

• Filing date: Jul 13, 2005
• Grant date: Mar 13, 2012
• Expiry date: Jun 15, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/549
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a “street-safe” version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.