Pyridine derivatives as dipeptedyl peptidase inhibitors

US8133907B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Larry C. Blaszczak · Indianapolis, US
• Brian Michael Mathes · Indianapolis, US
• Shon Pulley · Carmel, US
• Michael Alan Robertson · Indianapolis, US
• Scott Martin Sheehan · Carmel, US
• Qing Shi · Princeton, US
• Brian Morgan Watson · Carmel, US
• Michael Robert Wiley · Zionsville, US

Key dates

• Filing date: Jul 14, 2006
• Grant date: Mar 13, 2012
• Expiry date: Jun 6, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/38
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (1); X is selected from CH, CF and N; R5 is selected from H, C1-C6 alkyl, C1-C6 fluoroalkyl, and —OR12; R9 is selected from H —NR13C(O)R14 and —C(O)NR10R11; R12 is selected from H, C1-C6 alkyl and C3-C6 cycloalkyl, for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.