Heteroaryl derivatives of N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-amine

US8133908B2 · kind B2 · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• Giuseppe Alvaro · Stevenage, GB
• David Amantini · Romainville, FR
• Emiliano Castiglioni · Verona, IT
• Romano Di Fabio · Verona, IT
• Francesca Pavone · Verona, IT

Key dates

• Filing date: Nov 30, 2009
• Grant date: Mar 13, 2012
• Expiry date: Nov 30, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives having the following formula:wherein m, n, Het, R1, R2 and R3 are as defined herein, and their use as orexin antagonists.