Patent · US Active

Substituted indeno [1,2-b]indole derivatives as novel inhibitors of protein kinase CK2 and their use as tumor therapeutic agents, cytostatics and diagnostic aids

US8133913B2 · kind B2 · utility

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43Claims

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Assignee

Heinrich-Heine-Universitat Dusseldorf · DE

Inventors

Hans-Jorg Hemmerling · Mettmann, DE
Claudia Götz · Saarburg, DE
Joachim Jose · Mülheim an der Ruhr, DE

Key dates

Filing date	Oct 4, 2007
Grant date	Mar 13, 2012
Priority date	—
Expiry date	Oct 4, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Synthesis of novel substituted indeno[1,2-b]indole derivatives of the type of 5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-diones and 5H-indeno[1,2-b]indole-6,9,10-triones, which show pronounced inhibition of the human protein kinase CK2, and the use thereof as active ingredients in medicaments and/or drug products in particular for the treatment of neoplastic diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.