Elimination of heterogeneous or mixed cell population in tumors
US8137669B2 · kind B2 · utility
7Cited by
2References
5Claims
0Family size
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Key dates
| Filing date | Aug 5, 2008 |
| Grant date | Mar 20, 2012 |
| Priority date | — |
| Expiry date | Dec 7, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.