Polyconjugates for in vivo delivery of polynucleotides
US8137695B2 · kind B2 · utility
66Cited by
19References
27Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 17, 2007 |
| Grant date | Mar 20, 2012 |
| Priority date | — |
| Expiry date | Aug 17, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0362
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.