Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1

US8138178B2 · kind B2 · utility

Assignees

• Vitae Pharmaceuticals, LLC · US
• Boehringer Ingelheim International GmbH · DE

Inventors

• David A. Claremon · Audubon, US
• Linghang Zhuang · Doylestown, US
• Katerina Leftheris · Skillman, US
• Colin M. Tice · Ambler, US
• Zhenrong Xu · Forest Park, US
• Yuanjie Ye · Ambler, US
• Suresh B. Singh · Kendall Park, US
• Salvacion Cacatian · Conshohocken, US
• Wei Zhao · North Potomac, US

Key dates

• Filing date: Apr 30, 2009
• Grant date: Mar 20, 2012
• Expiry date: Apr 30, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a compound represented by Formula (Im1)or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Also disclosed are pharmaceutical compositions comprising the compound of Formula (Im1) or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof and methods of inhibiting 11β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formulas (Im1), or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.