Synthesis of cyclen derivatives

US8138332B2 · kind B2 · utility

Assignee

• GE HEALTHCARE AS · NO

Inventors

• Oskar Axelsson · Malmö, SE
• Andreas Olsson · Oslo, NO

Key dates

• Filing date: Apr 18, 2006
• Grant date: Mar 20, 2012
• Expiry date: Feb 4, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D257/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to an improved process for preparation of protected DO3A, such as DO3A-tri-t-butyl ester (1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tri-t-butyl ester). The compound is prepared as a salt. The process includes a work-up procedure giving DO3A-tri-t-butyl ester as a salt of excellent purity.