Aurora kinase inhibitors from an encoded small molecule library
US8138338B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Jul 27, 2007 |
| Grant date | Mar 20, 2012 |
| Priority date | — |
| Expiry date | Jul 27, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, at least in part, compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z1, Z2, Z3, R1, x, y, R2, R3, R4a, R4b, R5, R6 and R7 are described herein, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use as Aurora A kinase inhibitors in treatment, e.g., of cancer and other proliferative disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.