Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response

US8142819B2 · kind B2 · utility

Assignee

• METAPROTEOMICS, LLC · US

Inventors

• Matthew L. Tripp · Gig Harbor, US
• John G. Babish · Ithaca, US
• Jeffrey S. Bland · West Richland, US
• Gary Darland · Port Orchard, US
• Robert Lerman · Gig Harbor, US
• Daniel O. Lukaczer · Gig Harbor, US
• DeAnn J. Liska · Gig Harbor, US
• Terrence Howell · Brookline, US

Key dates

• Filing date: Jun 18, 2003
• Grant date: Mar 27, 2012
• Expiry date: Jun 18, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.