Methods of cleaving DNA with rationally-designed meganucleases
US8143016B2 · kind B2 · utility
10Cited by
20References
30Claims
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Key dates
| Filing date | Sep 27, 2011 |
| Grant date | Mar 27, 2012 |
| Priority date | — |
| Expiry date | Sep 27, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.