High production system for infectious hepatitis C virus particle
US8143022B2 · kind B2 · utility
1Cited by
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5Claims
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Key dates
| Filing date | Sep 29, 2006 |
| Grant date | Mar 27, 2012 |
| Priority date | — |
| Expiry date | Nov 16, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/24252
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for producing infectious hepatitis C virus (HCV) particles, comprising a step of introducing an expression vector into a cell that allows HCV proliferation, such expression vector comprising: DNA sequences encoding the 5′ untranslated region, structural proteins, and, if necessary, non-structural proteins of HCV and DNA sequences encoding non-structural proteins and the 3′ untranslated region derived from the HCV JFH1 strain, which are located downstream of a polymerase I promoter; and a DNA fragment containing an RNA polymerase I terminator, which is located further downstream thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.