Patent · US Active

Production of N-acylated sulphur-containing amino acids with microorganisms having enhanced N-acyltransferase enzymatic activity

US8143031B2 · kind B2 · utility

2Cited by

0References

17Claims

0Family size

Assignee

METABOLIC EXPLORER · FR

Inventors

Rainer Figge · Le Crest, FR
Guillaume Barbier · Davis, US
Gwénaëlle Bestel-Corre · Riom, FR

Key dates

Filing date	Feb 12, 2009
Grant date	Mar 27, 2012
Priority date	—
Expiry date	Apr 26, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N9/1029
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing amino acids. The isolation of the N-acylated sulphur-containing amino acids from the fermentation medium is also claimed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.