Synthesis of oligo/poly(catechins) and methods of use

US8143308B2 · kind B2 · utility

Assignees

• University of Massachusetts Lowell · US
• The United States of America as represented by the Secretary of the Army · US

Inventors

• Ferdinando Bruno · Andover, US
• Jayant Kumar · Westford, US
• Subhalakshmi Nagarajan · Avon, US
• Susan J. Braunhut · Wellesley, US
• Ramaswamy Nagarajan · Dracut, US
• Lynne A. Samuelson · Marlborough, US
• Donna McIntosh · Chelmsford, US
• Klaudia Foley · Littleton, US

Key dates

• Filing date: Oct 29, 2007
• Grant date: Mar 27, 2012
• Expiry date: Jan 24, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08H6/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.