Thyroid like compounds

US8143424B2 · kind B2 · utility

Assignee

• Torrent Pharmaceuticals Limited · IN

Inventors

• Laxmikant Chhipa · Mahesana, IN
• Shitalkumar Zambad · Sayla, IN
• Ramesh Gupta · Prospect, US
• Davinder Tuli · Gandhinagar, IN
• Ashok Kasundra · Sayla, IN
• Siralee Munshi · Sayla, IN
• M. Amir Siddiqui · Sayla, IN
• Subrat Kumar Bhattamisra · Sayla, IN
• Chaitanya Dutt · Gandhinagar, IN
• Vijay Chauthaiwale · Gandhinagar, IN

Key dates

• Filing date: Jun 2, 2008
• Grant date: Mar 27, 2012
• Expiry date: Apr 28, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel thyroid like compounds of formula (I), wherein R1, R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition and use thereof. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions including obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.