Method for producing aminoacetylpyrrolidinecarbonitrile derivative
US8143427B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Mar 21, 2008 |
| Grant date | Mar 27, 2012 |
| Priority date | — |
| Expiry date | Mar 21, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
It is to provide a method for efficiently producing an aminoacetylpyrrolidinecarbonitrile derivative which is useful as a DPP-IV inhibitor. It is a method for producing an aminoacetylpyrrolidinecarbonitrile derivative represented by the formula (2):(in the formula, A and R1 are as defined in the following), comprising allowing an acid to act on an aminoacetylpyrrolidinecarboxamide derivative represented by the formula (1):(in the formula, A represents CH2, CHF or CF2; and R1 represents a secondary amino group which may be substituted), and then allowing a dehydrating agent to act thereon.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.