Patent · US Active

Methods for renal neuromodulation

US8145317B2 · kind B2 · utility

470Cited by
327References
28Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMar 6, 2006
Grant dateMar 27, 2012
Priority date
Expiry dateDec 17, 2028

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61N1/3627
  • WIPO fieldMedical technology
  • WIPO sectorInstruments

Abstract

Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.