Sugar chain containing 4-position halogenated galactose and application thereof
US8148112B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 14, 2006 |
| Grant date | Apr 3, 2012 |
| Priority date | — |
| Expiry date | Jun 21, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to, for example, an oligosaccharide having at an end thereof a 4-position halogenated galactose residue represented by formula (I): (whereinX represents a halogen atom, and R represents a monosaccharide, an oligosaccharide, or a carrier), a transferase inhibitor containing the oligosaccharide, and a method for inhibiting sugar chain elongation reaction in the presence of glycosyltransferase, the method including employing the inhibitor. The invention also provides a method for producing a 4-position halogenated galactose sugar nucleotide represented by formula (II):(wherein each of R1 to R3 represents a hydroxyl group, an acetyl group, a halogen atom, or a hydrogen atom; X represents a halogen atom; and M represents a hydrogen ion or a metal ion), wherein the method employs bacterium-derived galactokinase and bacterium-derived hexose-1-phosphate uridylyltransferase. The invention is also directed to a sugar chain containing 4-position halogenated galactose envisaged to be employed as drugs and other materials, and to applications of the compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.