Differentiation of primate pluripotent cells to hepatocyte-lineage cells

US8148151B2 · kind B2 · utility

Assignees

• Geron Corporation · US
• The University Court of the University of Edinburgh · GB

Inventors

• Debiao Zhao · Edinburgh, GB
• Anish Sen Majumdar · Mumbai, IN
• David C. Hay · Gorebridge, GB
• Wei Cui · London, GB

Key dates

• Filing date: Jun 1, 2007
• Grant date: Apr 3, 2012
• Expiry date: Jan 26, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2506/02
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce hepatocyte-lineage cells. In certain embodiments, the population of cells produced by the methods is further enriched for hepatocyte-lineage cells.