Chemoenzymatic methods for the synthesis of statins and statin intermediates

US8148324B2 · kind B2 · utility

Assignee

• Verenium Corporation · US

Inventors

• William Greenberg · San Diego, US
• Mark J. Burk · Cambridge, GB
• Alexander Varvak · San Diego, US
• Kelvin Wong · San Diego, US

Key dates

• Filing date: Feb 15, 2008
• Grant date: Apr 3, 2012
• Expiry date: Apr 14, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P17/12
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R—(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.