Method for modulating responsiveness to steroids

US8148341B2 · kind B2 · utility

Assignee

• Index Pharmaceuticals AB · SE

Inventors

• Ann-Kristin Spiik · Tullinge, SE
• Robert Lofberg · Djursholm, SE
• Lisa Charlotta Bandholtz · Stockholm, SE
• Oliver Von Stein · Upplands Väsby, SE

Key dates

• Filing date: Jun 30, 2006
• Grant date: Apr 3, 2012
• Expiry date: May 31, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3233
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention makes it possible to enhance steroid efficacy in a steroid refractory patient afflicted with an inflammatory condition not responding or responding poorly or inadequately to anti-inflammatory treatment, by administering an effective amount of an oligonucleotide having the sequence 5′-Xm-TTCGT-Yn-3′ to 5 said patient, wherein X is A, T, C or G, Y is A, T, C or G, m=0-7, n=0-7 and wherein at least one CG dinucleotide is unmethylated. The invention also encompasses the use of said oligonucleotide for the manufacture of pharmaceuticals.