Binding molecules capable of neutralizing rabies virus and uses thereof

US8148497B2 · kind B2 · utility

Assignee

• Crucell Holland B.V. · NL

Inventors

• Alexander Berthold Hendrik Bakker · Utrecht, NL
• Willem Egbert Marissen · Leiden, NL
• Robert A. Kramer · Crown Point, US
• Cornelis Adriaan De Kruif · De Bilt, NL

Key dates

• Filing date: Jul 6, 2009
• Grant date: Apr 3, 2012
• Expiry date: Feb 13, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/20122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. Preferably, they can be used in the post-exposure prophylaxis of rabies.