Process for the synthesis of anticancer (poly) aminoalkylaminoacetamide derivatives of epipodophyllotoxin
US8148552B2 · kind B2 · utility
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Key dates
| Filing date | Sep 23, 2008 |
| Grant date | Apr 3, 2012 |
| Priority date | — |
| Expiry date | Feb 17, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes a new process for the preparation of (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin useful for their applications in therapeutics as anticancer agents. This process comprises a step of condensation of a primary-amine-containing reactant, whose amine functions are not protected, with β-chloroacetamido-4′-epipodophyllotoxin in a polar aprotic organic solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.