Active control of epileptic seizures and diagnosis based on critical systems-like behavior

US8150522B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Javier Echauz · Roswell, US
• Gregory A. Worrell · Rochester, US
• Brian Litt · Yeadon, US

Key dates

• Filing date: Aug 18, 2006
• Grant date: Apr 3, 2012
• Expiry date: Jan 26, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/36135
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Developing a measure of critical systems-like behavior in an epilepsy patient in order to map epileptic networks, either passively or evoking responses through subthreshold stimulation, and to apply “therapeutic” stimulations to the patient that cause smaller, but more frequent dissipations of “energy,” a transcription product, subclinical electrophysiological activity or seizures in order to raise the clinical seizure initiation threshold, through releasing accumulated interictal energy in a seizure onset zone or elsewhere in the epileptic network, thereby preventing occurrence of larger more debilitating seizures.