Patent · US Active

Conjugates of photo-activatable dyes

US8153103B2 · kind B2 · utility

1Cited by

2References

33Claims

0Family size

Assignee

The Board of Regents of the University of Texas System · US

Inventors

Wen-Hong Li · Dallas, US
Yan Guo · Westfield, US

Key dates

Filing date	Jul 1, 2009
Grant date	Apr 10, 2012
Priority date	—
Expiry date	Jul 12, 2030

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/689
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A new class of photoactivatable dyes provides the ability to study cell-cell communication in live animals non-invasively with high spatiotemporal resolution. The compositions are made up of a macromolecule, a caging group, and a coumarin dye. Upon photolysis, the coumarin dye is released from the macromolecule caging group complex and is freely diffusible in cells and between cells. The compositions are retained in cells very well, having no observable side effects, no susceptibility to metabolism, and the ability to generate bright fluorescence signals after photolysis. Because of their high loading capacity and long cellular retention, they can be selectively uncaged in specific cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.