Patent · US Active

Environment-responding siRNA carrier using disulfide-cross-linked polymeric micelle

US8153110B2 · kind B2 · utility

5Cited by

1References

12Claims

0Family size

Assignee

THE UNIVERSITY OF TOKYO · JP

Inventors

Kazunori Kataoka · Bunkyo, JP
Nobuhiro Nishiyama · Tokyo, JP
Satoru Matsumoto · Tokyo, JP

Key dates

Filing date	Nov 22, 2007
Grant date	Apr 10, 2012
Priority date	—
Expiry date	Nov 22, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition, and a gene therapy agent, each of which uses the complex. The polyion complex is characterized by comprising: a block copolymer composed of a polyethylene glycol moiety and a polycation moiety having a thiol group as a side chain at the terminus; and siRNA.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.