Immunostimulatory G, U-containing oligoribonucleotides

US8153141B2 · kind B2 · utility

Assignee

• COLEY PHARMACEUTICAL GMBH · DE

Inventors

• Grayson B. Lipford · Watertown, US
• Stefan Bauer · Alzey, DE
• Hermann Wagner · Unterschleißheim, DE

Key dates

• Filing date: Apr 4, 2003
• Grant date: Apr 10, 2012
• Expiry date: Jan 24, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/17
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). The compositions and methods are useful for stimulating immune activation. Methods useful for screening candidate immunostimulatory compounds are also provided.