Patent · US Active

Method for detecting and quantifying rare mutations/polymorphisms

US8153377B2 · kind B2 · utility

2Cited by
5References
6Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 1, 2009
Grant dateApr 10, 2012
Priority date—
Expiry dateJul 1, 2029

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q2600/156
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic acid change or mutation, such as deletion, insertion, translocation, inversion, one or more base substitution or polymorphism. Therefore, the methods of the present invention are useful in detection of rare mutations in, for example, diagnostic, prognostic and follow-up applications, when the targets are rare known nucleic acid variants mixed in with the wildtype or the more common nucleic acid variant(s).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.