Polynucleotides encoding stop codons in multiple reading frames and methods of use
US8153420B2 · kind B2 · utility
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Key dates
| Filing date | Jul 31, 2008 |
| Grant date | Apr 10, 2012 |
| Priority date | — |
| Expiry date | Oct 18, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/8218
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Compositions having polynucleotides encoding multiple translational stop signals in more than one reading frame are provided. The compositions include isolated polynucleotides, expression cassettes, and vectors, as well as host cells, prokaryotic organisms, and eukaryotic organisms comprising the polynucleotide(s). Methods include using the polynucleotides to stop translation of an mRNA into a protein, to produce a transformed cell and/or organism comprising the polynucleotide, and to identify transformed cells or organisms of a specific lineage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.